https://nova.newcastle.edu.au/vital/access/ /manager/Index ${session.getAttribute("locale")} 5 https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:29013 P < 2 × 10⁻¹⁶). Further, the gene set analyses revealed several miRNAs regulating schizophrenia risk genes, with the strongest enrichment for targets of miR-9-5p (P = .0056 for enrichment among the top 1% most-associated single-nucleotide polymorphisms, corrected for multiple testing). It is further of note that MIR9-2 is located in a genomic region showing strong evidence for association with schizophrenia (P = 7.1 × 10⁻⁸). The second and third strongest gene set signals were seen for the targets of miR-485-5p and miR-137, respectively. Conclusions and Relevance: This study provides evidence for a role of miR-9-5p in the etiology of schizophrenia. Its implication is of particular interest as the functions of this neurodevelopmental miRNA tie in with established disease biology: it has a regulatory loop with the fragile X mental retardation homologue FXR1 and regulates dopamine D₂ receptor density.]]> Wed 11 Apr 2018 15:28:50 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:44746 Tue 21 Mar 2023 16:53:58 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:38229 Mon 16 Aug 2021 17:39:39 AEST ]]>